James R. Heath, PhD

President and Professor

ISB

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Dr. James R. Heath is President and Professor at Institute for Systems Biology in Seattle. Heath also has the position of Professor of Molecular and Medical Pharmacology at UCLA. Formerly, he was the Elizabeth W. Gilloon Professor of Chemistry at Caltech, and served as co-director of the Parker Institute for Cancer Immunotherapy at UCLA until 2017.

Heath has had a profound impact on ISB since taking over leadership in 2018. He continues to make important discoveries in the field of cancer immunotherapy, and in 2022 was selected to lead a National Cancer Institute Comprehensive Cancer Center to study sequential targeted inhibitors and immunotherapies.

At the beginning of the COVID-19 pandemic, Heath quickly pivoted the focus of his lab and collaboratively worked with others within and beyond ISB to uncover secrets behind COVID-19 and long COVID. He published research that has changed how COVID-19 is understood, and now leads the Pacific Northwest consortium of the NIH-funded RECOVER study, which aims to understand the long-term effects of COVID.

Heath received his PhD in 1988 from Rice University, where he was the principal graduate student involved in the discovery of C60 and the fullerenes. He was a Miller Fellow at UC Berkeley before joining the research staff at IBM Watson Labs in 1991. He took a faculty position at UCLA in 1994, and moved to Caltech in 2003.

He has received several awards and honors, including the Irving Weinstein Award from the American Association of Cancer Researchers, and the Sackler Prize in the Physical Sciences. In 2009, he was named one of the top seven innovators in the world by Forbes Magazine.

Heath has founded or co-founded several companies, including PACT Pharma, Integrated Diagnostics, Indi Molecular, CTI Molecular Imaging (acquired by Siemens in 2005), Sofie Biosciences, Isoplexis, and NanoSys.

2018-
President and Professor, Institute for Systems Biology, Seattle

2003-2018
Elizabeth W. Gilloon Professor & Professor of Chemistry, Caltech

2001-
Professor of Molecular & Medical Pharmacology, UCLA Health Sciences Center

1997-2002
Prof., UCLA; 1996-97, Assoc. Prof., UCLA; 1994-96, Asst. Prof., UCLA

1991 – 94
Research Staff, IBM T.J. Watson Res. Labs, Yorktown, NY

1988-1991
UC Berkeley Miller Fellowship, Postdoctoral Scholar

1988
Rice University, PhD, Chemistry

1988
Rice University, MA, Chemistry

1984
Baylor University, BSc, Chemistry

Kornilov, S. A., Price, N. D., Gelinas, R., Acosta, J., Brunkow, M. E., Gervasi-Follmar, T., Winger, R. C., Aldershoff, D., Lausted, C., Troisch, P., Smith, B., Heath, J. R., Repovic, P., Cohan, S., & Magis, A. T. (2024). Multi-Omic characterization of the effects of Ocrelizumab in patients with relapsing-remitting multiple sclerosis. Journal of the Neurological Sciences, 467, 123303. https://doi.org/10.1016/j.jns.2024.123303 Cite

Swank, Z., Borberg, E., Senussi, Y., Manickas-Hill, Z., Chen, Y., Chalise, S., Yu, X. G., Hadlock, J., Alex, H., Heath, J. R., Li, S., Magis, A. T., Murray, K. M., Goldman, J. D., Edmark, R. A., & Gutierrez, V. (2024). Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study. Clinical Microbiology and Infection. https://doi.org/10.1016/j.cmi.2024.09.001 Cite

Matuozzo, D., Talouarn, E., Marchal, A., Zhang, P., Manry, J., Seeleuthner, Y., Zhang, Y., Bolze, A., Chaldebas, M., Milisavljevic, B., Gervais, A., Bastard, P., Asano, T., Bizien, L., Barzaghi, F., Abolhassani, H., Tayoun, A. A., Aiuti, A., Darazam, I. A., … Cobat, A. (2024). Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Genome Medicine, 16(1), 6. https://doi.org/10.1186/s13073-023-01278-0 Cite Download

Armstrong, S. S., Chen, D. G., Kumar, S., Heath, J. R., Feinstein, M., Greenland, J. R., Calabrese, D. R., Lanier, L. L., Ley, K., & Shemesh, A. (2024). CITE-seq analysis reveals human cytomegalovirus and diabetes-associated adaptive NK cell alterations in cardiovascular disease. BioRxiv, 2024–03. https://www.biorxiv.org/content/10.1101/2024.03.22.581997.abstract Cite Download

Faust, S. N., Haynes, R., Jones, C. E., Staplin, N., Whittaker, E., Jaki, T., Juszczak, E., Spata, E., Wan, M., & Heath, J. R. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Child & Adolescent Health, 8(3), 190–200. https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(23)00316-4/fulltext Cite

Heath, J. R. (2024). Abstract SY41-02: Experimental methods for high throughput discovery and validation of tumor antigens. Cancer Research, 84(7_Supplement), SY41-02. https://aacrjournals.org/cancerres/article/84/7_Supplement/SY41-02/742137 Cite

Flower, C. T., Liu, C., Chuang, H.-Y., Ye, X., Cheng, H., Heath, J. R., Wei, W., & White, F. M. (2024). Signaling and transcriptional dynamics underlying early adaptation to oncogenic BRAF inhibition. BioRxiv, 2024–02. https://www.biorxiv.org/content/10.1101/2024.02.19.581004.abstract Cite Download

Kim, J., Ng, R. H., Liang, J., Johnson, D., Shin, Y. S., Chatziioannou, A. F., Phelps, M. E., Wei, W., Levine, R. D., & Heath, J. R. (2024). Kinetic Trajectories of Glucose Uptake in Single Cancer Cells Reveal a Drug-Induced Cell-State Change Within Hours of Drug Treatment. The Journal of Physical Chemistry. B. https://doi.org/10.1021/acs.jpcb.4c03663 Cite

Nguyen, K. T., Rima, X. Y., Nguyen, L. T. H., Wang, X., Kwak, K. J., Yoon, M. J., Li, H., Chiang, C.-L., Doon-Ralls, J., Scherler, K., Fallen, S., Godfrey, S. L., Wallick, J. A., Magaña, S. M., Palmer, A. F., Lee, I., Nunn, C. C., Reeves, K. M., Kaplan, H. G., … Reátegui, E. (2024). Integrated Antigenic and Nucleic Acid Detection in Single Virions and Extracellular Vesicles with Viral Content. Advanced Healthcare Materials, e2400622. https://doi.org/10.1002/adhm.202400622 Cite

Chen, D. G., Xie, J., Choi, J., Ng, R. H., Zhang, R., Li, S., Edmark, R., Zheng, H., Solomon, B., Campbell, K. M., Medina, E., Ribas, A., Khatri, P., Lanier, L. L., Mease, P. J., Goldman, J. D., Su, Y., & Heath, J. R. (2024). Integrative systems biology reveals NKG2A-biased immune responses correlate with protection in infectious disease, autoimmune disease, and cancer. Cell Reports, 43(3). https://doi.org/10.1016/j.celrep.2024.113872 Cite Download

Thaweethai, T., Jolley, S. E., Karlson, E. W., Levitan, E. B., Levy, B., McComsey, G. A., McCorkell, L., Nadkarni, G. N., Parthasarathy, S., Singh, U., Walker, T. A., Selvaggi, C. A., Shinnick, D. J., Schulte, C. C. M., Atchley-Challenner, R., Alba, G. A., Alicic, R., Altman, N., Anglin, K., … RECOVER Consortium. (2023). Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. JAMA, 329(22), 1934–1946. https://doi.org/10.1001/jama.2023.8823 Cite Download

Foy, S., Wang, C., Yuen, B., Said, S., Quach, B., Hoover, J., Nayak, S., Hunter, T., Pan, Z., Smith, C., Borrman, T., Stawiski, E., Ng, A. H. C., Lu, Y., Heath, J. R., & Mandl, S. (2023). Abstract 901: Monitoring of neoantigens and adoptively transferred personalized neoTCR T cell populations in the tumor and PBMCs of patients with solid tumors. Cancer Research, 83(7_Supplement), 901. https://doi.org/10.1158/1538-7445.AM2023-901 Cite

Heath, J. R., Chen, D., Xie, J., Choi, J., Ng, R., Zhang, R., Li, S., Edmark, R., Zheng, H., Solomon, B., Campbell, K., Medina, E., Ribas, A., Khatri, P., Lanier, L., Mease, P., Goldman, J., & Su, Y. (2023). An NKG2A biased immune response confers protection for infection, autoimmune disease, and cancer [Preprint]. In Review. https://doi.org/10.21203/rs.3.rs-3413673/v1 Cite Download

Chen, D. G., Xie, J., Su, Y., & Heath, J. R. (2023). T cell receptor sequences are the dominant factor contributing to the phenotype of CD8+ T cells with specificities against immunogenic viral antigens. Cell Reports, 42(11), 113279. https://doi.org/10.1016/j.celrep.2023.113279 Cite

Cheng, H., Tang, Y., Li, Z., Guo, Z., Heath, J. R., Xue, M., & Wei, W. (2023). Non-Mass Spectrometric Targeted Single-Cell Metabolomics. Trends in Analytical Chemistry: TRAC, 168, 117300. https://doi.org/10.1016/j.trac.2023.117300 Cite

Ng, A. H. C., Hu, H., Wang, K., Scherler, K., Warren, S. E., Zollinger, D. R., McKay-Fleisch, J., Sorg, K., Beechem, J. M., Ragaglia, E., Lacy, J. M., Smith, K. D., Marshall, D. A., Bundesmann, M. M., López de Castilla, D., Corwin, D., Yarid, N., Knudsen, B. S., Lu, Y., … Heath, J. R. (2023). Organ-specific immunity: A tissue analysis framework for investigating local immune responses to SARS-CoV-2. Cell Reports, 42(10), 113212. https://doi.org/10.1016/j.celrep.2023.113212 Cite Download

Nag, A., Mafi, A., Das, S., Yu, M. B., Alvarez-Villalonga, B., Kim, S.-K., Su, Y., Goddard, W. A., & Heath, J. R. (2023). Stereochemical engineering yields a multifunctional peptide macrocycle inhibitor of Akt2 by fine-tuning macrocycle-cell membrane interactions. Communications Chemistry, 6(1), 95. https://doi.org/10.1038/s42004-023-00890-w Cite Download

Finton, K. A. K., Rupert, P. B., Friend, D. J., Dinca, A., Lovelace, E. S., Buerger, M., Rusnac, D. V., Foote-McNabb, U., Chour, W., Heath, J. R., Campbell, J. S., Pierce, R. H., & Strong, R. K. (2023). Effects of HLA single chain trimer design on peptide presentation and stability. Frontiers in Immunology, 14, 1170462. https://doi.org/10.3389/fimmu.2023.1170462 Cite Download

Flower, C. T., Liu, C., Heath, J. R., Wei, W., & White, F. M. (2023). Abstract 4876: A systems pharmacology approach to discover synergistic targeted therapy combinations. Cancer Research, 83(7_Supplement), 4876. https://doi.org/10.1158/1538-7445.AM2023-4876 Cite

Chour, W., Choi, J., Xie, J., Chaffee, M. E., Schmitt, T. M., Finton, K., DeLucia, D. C., Xu, A. M., Su, Y., Chen, D. G., Zhang, R., Yuan, D., Hong, S., Ng, A. H. C., Butler, J. Z., Edmark, R. A., Jones, L. C., Murray, K. M., Peng, S., … Heath, J. R. (2023). Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis. Communications Biology, 6(1), 528. https://doi.org/10.1038/s42003-023-04899-8 Cite Download

Xu, A. M., Chour, W., DeLucia, D. C., Su, Y., Pavlovitch-Bedzyk, A. J., Ng, R., Rasheed, Y., Davis, M. M., Lee, J. K., & Heath, J. R. (2023). Entropic analysis of antigen-specific CDR3 domains identifies essential binding motifs shared by CDR3s with different antigen specificities. Cell Systems, 14(4), 273-284.e5. https://doi.org/10.1016/j.cels.2023.03.001 Cite

Matuozzo, D., Talouarn, E., Marchal, A., Zhang, P., Manry, J., Seeleuthner, Y., Zhang, Y., Bolze, A., Chaldebas, M., Milisavljevic, B., Gervais, A., Bastard, P., Asano, T., Bizien, L., Barzaghi, F., Abolhassani, H., Abou Tayoun, A., Aiuti, A., Alavi Darazam, I., … Cobat, A. (2023). Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Genome Medicine, 15(1), 22. https://doi.org/10.1186/s13073-023-01173-8 Cite Download

Solomon, B. D., Zheng, H., Dillon, L. W., Goldman, J. D., Hourigan, C. S., Heath, J. R., & Khatri, P. (2023). Prediction of HLA genotypes from single-cell transcriptome data. Frontiers in Immunology, 14, 1146826. https://doi.org/10.3389/fimmu.2023.1146826 Cite Download

Horwitz, L. I., Thaweethai, T., Brosnahan, S. B., Cicek, M. S., Fitzgerald, M. L., Goldman, J. D., Hess, R., Hodder, S. L., Jacoby, V. L., Jordan, M. R., Krishnan, J. A., Laiyemo, A. O., Metz, T. D., Nichols, L., Patzer, R. E., Sekar, A., Singer, N. G., Stiles, L. E., Taylor, B. S., … Foulkes, A. S. (2023). Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PloS One, 18(6), e0286297. https://doi.org/10.1371/journal.pone.0286297 Cite Download

Puig-Saus, C., Sennino, B., Peng, S., Wang, C. L., Pan, Z., Yuen, B., Purandare, B., An, D., Quach, B. B., Nguyen, D., Xia, H., Jilani, S., Shao, K., McHugh, C., Greer, J., Peabody, P., Nayak, S., Hoover, J., Said, S., … Ribas, A. (2023). Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy. Nature. https://doi.org/10.1038/s41586-023-05787-1 Cite

Stawiski, E. W., Bhardwaj, V., Mathur, J., Huang, E., Dalmas, O., Pan, Z., Wang, C., Heath, J. R., Sennino, B., Frohlich, M., Rao, A., & Mandl, S. (2022). Abstract 2757: Correlates of peptide-HLA manufacturing success, TCR capture and neoTCR trafficking from patients using the PACTImmune࣪ Database. Cancer Research, 82(12_Supplement), 2757. https://doi.org/10.1158/1538-7445.AM2022-2757 Cite

Heath, J. R., Chour, W., Choi, J., Xie, J., Chaffee, M., Schmitt, T., Finton, K., Delucia, D., Xu, A., Su, Y., Chen, D., Zhang, R., Yuan, D., Hong, S., Ng, A., Butler, J., Edmark, R., Jones, L., Murray, K., … Greenberg, P. (2022). Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8+ T cell discovery and analysis. Research Square, rs.3.rs-1090664. https://doi.org/10.21203/rs.3.rs-1090664/v1 Cite Download

Saus, C. P., Sennino, B., Peng, S., Pan, Z., Yuen, B., Purandare, B., Jacoby, K., Dalmas, O., An, D., Quach, B., Wang, C., Xia, H., Jilani, S., Nguyen, D., Shao, K., McHugh, C., Greer, J., Peabody, P., Nayak, S., … Ribas, A. (2022). 123 Landscape analysis of the neoepitope-specific T cell responses in patients with and without clinical benefit from immune checkpoint blockade therapy. Journal for ImmunoTherapy of Cancer, 10(Suppl 2). https://doi.org/10.1136/jitc-2022-SITC2022.0123 Cite Download

Repovic, P., Choi, J., Hong, S., Reola, J., Chun, K., Petropoulos, C., Bowen, J., Qian, P., Evans, S., Edmark, R., Mendoza, J., Avila-Carey, R., Heath, J. R., & Goldman, J. (2022). Temporal Trends in Humoral and Cellular Immune Responses to SARS-CoV-2 mRNA Vaccines Among Multiple Sclerosis Patients Treated With Natalizumab, Ocrelizumab or Fumarates (P14-4.006). Neurology, 98(18 Supplement). https://n.neurology.org/content/98/18_Supplement/3523 Cite

Manry, J., Bastard, P., Gervais, A., Voyer, T. L., Rosain, J., Philippot, Q., Michailidis, E., Hoffmann, H.-H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., Prost, N. de, Tandjaoui-Lambiotte, Y., … Cobat, A. (2022). The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies (preprint). https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/dx.doi.org/10.21203/rs.3.rs-1225906/v1 Cite

Matuozzo, D., Talouarn, E., Marchal, A., Manry, J., Seeleuthner, Y., Zhang, Y., Bolze, A., Chaldebas, M., Milisavljevic, B., Zhang, P., Gervais, A., Bastard, P., Asano, T., Bizien, L., Barzaghi, F., Abolhassani, H., Tayoun, A. A., Aiuti, A., Darazam, I. A., … Cobat, A. (2022). Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19 (preprint). https://medrxiv.org/cgi/content/short/2022.10.22.22281221 Cite

Foy, S. P., Jacoby, K., Bota, D. A., Hunter, T., Pan, Z., Stawiski, E., Ma, Y., Lu, W., Peng, S., Wang, C. L., Yuen, B., Dalmas, O., Heeringa, K., Sennino, B., Conroy, A., Bethune, M. T., Mende, I., White, W., Kukreja, M., … Mandl, S. J. (2022). Non-viral precision T cell receptor replacement for personalized cell therapy. Nature. https://doi.org/10.1038/s41586-022-05531-1 Cite Download

Zaslavsky, M. E., Ram-Mohan, N., Guthridge, J. M., Merrill, J. T., Goldman, J. D., Lee, J.-Y., Roskin, K. M., Cunningham-Rundles, C., Moody, M. A., Haynes, B. F., Pinsky, B. A., Heath, J. R., James, J. A., Yang, S., Blish, C. A., Tibshirani, R., Kundaje, A., & Boyd, S. D. (2022). Disease diagnostics using machine learning of immune receptors. BioRxiv: The Preprint Server for Biology, 2022.04.26.489314. https://doi.org/10.1101/2022.04.26.489314 Cite Download

Matuozzo, D., Talouarn, E., Marchal, A., Manry, J., Seeleuthner, Y., Zhang, Y., Bolze, A., Chaldebas, M., Milisavljevic, B., Zhang, P., Gervais, A., Bastard, P., Asano, T., Bizien, L., Barzaghi, F., Abolhassani, H., Tayoun, A. A., Aiuti, A., Darazam, I. A., … Cobat, A. (2022). Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. MedRxiv: The Preprint Server for Health Sciences, 2022.10.22.22281221. https://doi.org/10.1101/2022.10.22.22281221 Cite Download

Thompson, R. C., Simons, N. W., Wilkins, L., Cheng, E., Del Valle, D. M., Hoffman, G. E., Cervia, C., Fennessy, B., Mouskas, K., Francoeur, N. J., Johnson, J. S., Lepow, L., Le Berichel, J., Chang, C., Beckmann, A. G., Wang, Y.-C., Nie, K., Zaki, N., Tuballes, K., … Beckmann, N. D. (2022). Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae. Nature Medicine. https://doi.org/10.1038/s41591-022-02107-4 Cite Download

Kornilov, S., Magis, A., Price, N. D., Gelinas, R., Heath, J. R., Acosta, J., Repovic, P., & Cohan, S. (2022). Initiation of ocrelizumab in patients with relapsing multiple sclerosis is associated with a broad immunomodulatory response implicating proinflammatory T-cells: a multi-omics study. Multiple Scleroisis Journal, 28(3), 763. Cite

Goldman, J. D., Wang, K., Röltgen, K., Nielsen, S. C. A., Roach, J. C., Naccache, S. N., Yang, F., Wirz, O. F., Yost, K. E., Lee, J.-Y., Chun, K., Wrin, T., Petropoulos, C. J., Lee, I., Fallen, S., Manner, P. M., Wallick, J. A., Algren, H. A., Murray, K. M., … Heath, J. R. (2022). Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report. Vaccines, 11(1), 5. https://doi.org/10.3390/vaccines11010005 Cite Download

Duvvuri, V. R., Baumgartner, A., Molani, S., Hernandez, P. V., Yuan, D., Roper, R. T., Matos, W. F., Robinson, M., Su, Y., Subramanian, N., Goldman, J. D., Heath, J. R., & Hadlock, J. J. (2022). Angiotensin-Converting Enzyme (ACE) Inhibitors May Moderate COVID-19 Hyperinflammatory Response: An Observational Study with Deep Immunophenotyping. Health Data Science, 2022, 0002. https://doi.org/10.34133/hds.0002 Cite Download

Shemesh, A., Su, Y., Calabrese, D. R., Chen, D., Arakawa-Hoyt, J., Roybal, K. T., Heath, J. R., Greenland, J. R., & Lanier, L. L. (2022). Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression. The Journal of Experimental Medicine, 219(11), e20220551. https://doi.org/10.1084/jem.20220551 Cite Download

Mao, Z., Nesterenko, P. A., McLaughlin, J., Deng, W., Burton Sojo, G., Cheng, D., Noguchi, M., Chour, W., DeLucia, D. C., Finton, K. A., Qin, Y., Obusan, M. B., Tran, W., Wang, L., Bangayan, N. J., Ta, L., Chen, C.-C., Seet, C. S., Crooks, G. M., … Witte, O. N. (2022). Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation. Proceedings of the National Academy of Sciences of the United States of America, 119(31), e2203410119. https://doi.org/10.1073/pnas.2203410119 Cite Download

Ng, R. H., Lee, J. W., Baloni, P., Diener, C., Heath, J. R., & Su, Y. (2022). Constraint-Based Reconstruction and Analyses of Metabolic Models: Open-Source Python Tools and Applications to Cancer. Frontiers in Oncology, 12, 914594. https://doi.org/10.3389/fonc.2022.914594 Cite Download

Manry, J., Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Michailidis, E., Hoffmann, H.-H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., de Prost, N., Tandjaoui-Lambiotte, Y., … Cobat, A. (2022). The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies. Proceedings of the National Academy of Sciences of the United States of America, 119(21), e2200413119. https://doi.org/10.1073/pnas.2200413119 Cite Download

Li, J., Zaslavsky, M., Su, Y., Guo, J., Sikora, M. J., van Unen, V., Christophersen, A., Chiou, S.-H., Chen, L., Li, J., Ji, X., Wilhelmy, J., McSween, A. M., Palanski, B. A., Mallajosyula, V. V. A., Bracey, N. A., Dhondalay, G. K. R., Bhamidipati, K., Pai, J., … Davis, M. M. (2022). KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science, 0(0), eabi9591. https://doi.org/10.1126/science.abi9591 Cite Download

Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., Kornilov, S. A., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Lee, I., Fallen, S., Dai, C. L., Baloni, P., … Heath, J. R. (2022). Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 0(0). https://doi.org/10.1016/j.cell.2022.01.014 Cite Download

Ross, M. K., Raji, C., Lokken, K. L., Bredesen, D. E., Roach, J. C., Funk, C. C., Price, N., Rappaport, N., Hood, L., & Heath, J. R. (2021). Case Study: A Precision Medicine Approach to Multifactorial Dementia and Alzheimer’s Disease. Journal of Alzheimer’s Disease & Parkinsonism, 11(Suppl 5), 018. Cite

Nesterenko, P. A., McLaughlin, J., Tsai, B. L., Burton Sojo, G., Cheng, D., Zhao, D., Mao, Z., Bangayan, N. J., Obusan, M. B., Su, Y., Ng, R. H., Chour, W., Xie, J., Li, Y.-R., Lee, D., Noguchi, M., Carmona, C., Phillips, J. W., Kim, J. T., … Witte, O. N. (2021). HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses. Cell Reports, 37(13), 110167. https://doi.org/10.1016/j.celrep.2021.110167 Cite Download

Jung, Y., Son, M., Nam, Y. R., Choi, J., Heath, J. R., & Yang, S. (2021). Microfluidic Single-Cell Proteomics Assay Chip: Lung Cancer Cell Line Case Study. Micromachines, 12(10), 1147. https://doi.org/10.3390/mi12101147 Cite Download

Jiang, Y., Duffy, F., Hadlock, J., Raappana, A., Styrchak, S., Beck, I., Mast, F. D., Miller, L. R., Chour, W., Houck, J., Armistead, B., Duvvuri, V. R., Yeung, W., Haglund, M., Wallner, J., Wallick, J. A., Hardy, S., Oldroyd, A., Ko, D., … Harrington, W. E. (2021). Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection. PloS One, 16(11), e0259902. https://doi.org/10.1371/journal.pone.0259902 Cite Download

Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Manry, J., Michailidis, E., Hoffmann, H.-H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., de Prost, N., Tandjaoui-Lambiotte, Y., … Casanova, J.-L. (2021). Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Science Immunology, 6(62), eabl4340. https://doi.org/10.1126/sciimmunol.abl4340 Cite Download