By integrating single-cell, proteomic, genetic, clinical, and laboratory data, the team found that these cells adopt molecular features also seen in established autoimmune diseases. The findings help explain how viral infections can disrupt immune regulation and may provide a framework for understanding and eventually preventing autoimmune complications following infection.
Researchers at the Institute for Systems Biology have developed a powerful new platform that can identify and deeply profile antigen-specific CD4+ T cells at unprecedented scale and resolution. Published in Nature Communications, the work could help accelerate vaccine design, improve immune monitoring, and advance next-generation cancer immunotherapies.
ISB President Dr. Jim Heath was included in Highly Cited Researchers 2018. The list is published by Clarivate Analytics, and recognizes “world-class researchers selected for their exceptional research performance, demonstrated by production of multiple highly cited papers that rank in the top 1 percent by citations for field and year in Web of Science.”